Your trusted partner for Nucleic Acid and Carbohydrate raw materials
GLYCOGENE

Your trusted partner for Nucleic Acid and Carbohydrate raw materials

GLYCOGENE

Products

To provide customers with customized products and services

-- Has cooperated with a number of domestic and international pharmaceutical and chemical companies

Glycogene was founded and led by world-leading synthetic chemistry scholar, who has over 30 years of extensive experience in biological and chemical synthesis. Glycogene has more than 200 employees, including 12 doctors and more than 40 masters. By integrating multiple synthetic technologies such as biosynthesis, fermentation and organic synthesis technologies, Glycogene focuse on offering high quality and cost-effective carbohydrates, nucleosides, nucleotides, phosphoramidites and protein structures. Also, we can provide custom synthesis services as needed. Glycogne has served hundreds of worldwide Pharma and Biotech.

Glycogene headquartered in Wuhan Optics Valley and has subsidiary located in North Carolina. Glycogene also has R & D centers and pilot-scale modern laboratories in Qingdao and Shenzhen,  manufacture in Panjin.

WHO ARE WE?

About GLYCOGENE


2019

Glycogene was founded in April 2019


250

More than 250 Employee


17500

The company covers over 17,500 square meters of corporate space


10

The company has been awarded 10 regional and international certificates


Facilities

Pepitites CRO

Technologies breakthrough in RNA field

2006: Nobel Prize for RNA Interference (RNAi) Mechanism Laid the Theoretical Foundation for Oligonucleotide Drugs

Fire & Mello elucidated the complete mechanism of siRNA-mediated gene silencing and were awarded the Nobel Prize in Physiology or Medicine.

2006: Nobel Prize for RNA Interference (RNAi) Mechanism Laid the Theoretical Foundation for Oligonucleotide Drugs

Fire & Mello elucidated the complete mechanism of siRNA-mediated gene silencing and were awarded the Nobel Prize in Physiology or Medicine.

2005-2010: Elucidation of Nucleobase Modification and Immune Interaction Resolved the Early Severe Immunotoxicity of Exogenous mRNA

Karikó & Weissman discovered that pseudouridine nucleobase modification can mitigate the strong innate immune inflammatory response induced by in vitro synthesized mRNA, while boosting protein production. This removed a critical barrier to the clinical application of mRNA.

2005-2010: Elucidation of Nucleobase Modification and Immune Interaction Resolved the Early Severe Immunotoxicity of Exogenous mRNA

Karikó & Weissman discovered that pseudouridine nucleobase modification can mitigate the strong innate immune inflammatory response induced by in vitro synthesized mRNA, while boosting protein production. This removed a critical barrier to the clinical application of mRNA.

2014: Birth of GalNAc Liver-Targeted Delivery Technology — A Breakthrough for Oligonucleotide Industrialization

Alnylam and Ionis developed the GalNAc conjugate delivery system, enabling precise liver targeting, subcutaneous administration, and long-term gene silencing of oligonucleotides.

2014: Birth of GalNAc Liver-Targeted Delivery Technology — A Breakthrough for Oligonucleotide Industrialization

Alnylam and Ionis developed the GalNAc conjugate delivery system, enabling precise liver targeting, subcutaneous administration, and long-term gene silencing of oligonucleotides.

2018: Global First siRNA Drug Onpattro Approved — Nucleic Acid Drugs Officially Enter Commercialization

The FDA approved Alnylam’s Onpattro, the world’s first RNAi therapeutic, for the treatment of transthyretin amyloidosis.

2018: Global First siRNA Drug Onpattro Approved — Nucleic Acid Drugs Officially Enter Commercialization

The FDA approved Alnylam’s Onpattro, the world’s first RNAi therapeutic, for the treatment of transthyretin amyloidosis.

2020: Global Emergency Approval of mRNA COVID-19 Vaccines — Nucleic Acid Technology Achieved Mass Popularization

Amid the global COVID-19 pandemic, Pfizer-BioNTech and Moderna mRNA vaccines obtained emergency use authorization worldwide.

2020: Global Emergency Approval of mRNA COVID-19 Vaccines — Nucleic Acid Technology Achieved Mass Popularization

Amid the global COVID-19 pandemic, Pfizer-BioNTech and Moderna mRNA vaccines obtained emergency use authorization worldwide.

Technologies breakthrough in glycoscience field

2022

1990s: Chemical enzymatic glycan synthesis.

Upon decades of work by researchers such as Yukio Ito, Qihui Weng, Peter Seeberger, and Peng George Wang, chemical enzymatic glycan synthesi has moved from the laboratory to 'glycan factories'—where the combination of automation and AI-assisted synthesis will fundamentally rewrite the economic model for glycan acquisition.

1990s: Chemical enzymatic glycan synthesis. 1990s: Chemical enzymatic glycan synthesis.

2000s:Synthetic biology of glycans.

With the industrialization of HMOs, showcases the significant commercial feasibility of precisely fermenting glycan compounds. We are also actively expanding our presence in the synthetic biology industry and have scaled up the production of synthetic biology sugar products such as L-fucose and ManNAc.

2000s:Synthetic biology of glycans. 2000s:Synthetic biology of glycans.

2010s:Antibody-drug conjugate (ADC) glycoconjugation technology.

Glycans can serve as anchors for precise drug delivery. We has established an ADC conjugation platform based on glycan remodeling, offering glycan remodeling enzymes (glycosidases + glycosyltransferases) and copper-free click chemistry connection technologies.

2010s:Antibody-drug conjugate (ADC) glycoconjugation technology. 2010s:Antibody-drug conjugate (ADC) glycoconjugation technology.

2022:Click Chemistry

The awarding of the 2022 Nobel Prize in Chemistry to click chemistry and bioorthogonal chemistry marks a Nobel-level tool revolution in glycoscience, promoted all-round breakthroughs of glycobiology in aqueous-phase reaction, precise synthesis, in vivo labeling and drug development.

2022:Click Chemistry 2022:Click Chemistry

Blog Center

Working Together, Chasing the Light | Tangzhi Pharmaceutical 2025 New Year Gala


As the year turns and a new chapter unfolds, we look back on 2024, a year of progress and achievement for Tangzhi. This year, we held grand annual meetings in Wuhan, Qingdao, and Panjin, celebrating our successes together. Wuhan, as the headquarters of Tangzhi Pharmaceutical, holds our initial aspirations and dreams. In 2024, we achieved remarkable results. The company was successfully selected for Wuhan's "Backbone High-tech Enterprise Gazelle Plan" and recognized as a "Potential Unicorn" enterprise in the East Lake High-tech Development Zone, a "2024 Deloitte China High-Tech High-Growth 50 Strong" company, and a "2024 Deloitte Guanggu High-Tech High-Growth Top 20" company. Over the past year, Tangzhi Pharmaceutical has continued to focus on technological innovation and product development, resulting in steady revenue growth. At the Wuhan annual meeting, in his opening address, Chairman Wang Peng reviewed the outstanding achievements we made in technological innovation and market expansion, thanked every employee for their hard work, and looked forward to the new year, where we will continue to cultivate the fields of sugar and nucleic acids, providing even better products and services to global customers.

2025-01-27

Moving Forward with Honors, the Future is Bright | Tangzhi Pharmaceutical Ranks Among "Deloitte China's 2024 Top 50 High-Growth Technology Companies"


Recently, the "2024 Deloitte China Technology Fast 50" (hereinafter referred to as "China 50") was announced. Tangzhi Pharmaceutical, with its outstanding performance and rapid growth in the fields of sugar and nucleic acids, was honored to be on the list, ranking 15th with a revenue growth rate exceeding 690%! This honor is not only an affirmation of Tangzhi Pharmaceutical's innovative strength in the fields of sugar and nucleic acids, but also a commendation for its high-speed growth in a difficult environment. The Deloitte China Technology Fast 50 program has always been regarded as a "benchmark for high-growth companies globally." The selection of Tangzhi Pharmaceutical marks its leading position and strong competitiveness in the industry.

2025-01-21

New DNA-encoded chemical library technology to aid drug discovery and development


(Science and Technology Daily) Although researchers have made significant progress in the development of molecular therapies in recent years, the number of newly discovered active substances remains insufficient. Now, the DNA-encoded chemical library (DEL) technology, jointly developed by Harvard University in the US and ETH Zurich in Switzerland, offers a new solution. The technology can automate the synthesis and testing of billions of compounds in a matter of weeks, and can also be used to produce larger drug molecules that will act on targets that are difficult to reach with traditional small molecules.

2024-09-25