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GLYCOGENE

Your trusted partner for Nucleic Acid and Carbohydrate raw materials

GLYCOGENE

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GLYCOGENE

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WHO ARE WE?

About GLYCOGENE

Founded in 2019 by experts in nucleic acids, glycoscience, and enzyme evolution, Glycogene Inc. brings together a leadership team of U.S.-trained scientists with over 20 years of experience in research, biotechnology, and commercialization. The company is headquartered in Wuhan, with a U.S. subsidiary in North Carolina, and is supported by R&D centers and pilot-scale laboratories in Qingdao and Shenzhen, as well as manufacturing facilities in Panjin.

With 250+ employees, Glycogene operates a proprietary chemo-enzymatic synthesis platform that integrates advanced technologies in nucleic acid and glycan engineering. We are committed to providing high-quality, cost-effective products and services to accelerate global innovation in nucleic acid and glycan-related development.

Technologies breakthrough in RNA field

2006: Nobel Prize for RNA Interference (RNAi) Mechanism Laid the Theoretical Foundation for Oligonucleotide Drugs

Fire & Mello elucidated the complete mechanism of siRNA-mediated gene silencing and were awarded the Nobel Prize in Physiology or Medicine.

2006: Nobel Prize for RNA Interference (RNAi) Mechanism Laid the Theoretical Foundation for Oligonucleotide Drugs

Fire & Mello elucidated the complete mechanism of siRNA-mediated gene silencing and were awarded the Nobel Prize in Physiology or Medicine.

2005-2010: Elucidation of Nucleobase Modification and Immune Interaction Resolved the Early Severe Immunotoxicity of Exogenous mRNA

Karikó & Weissman discovered that pseudouridine nucleobase modification can mitigate the strong innate immune inflammatory response induced by in vitro synthesized mRNA, while boosting protein production. This removed a critical barrier to the clinical application of mRNA.

2005-2010: Elucidation of Nucleobase Modification and Immune Interaction Resolved the Early Severe Immunotoxicity of Exogenous mRNA

Karikó & Weissman discovered that pseudouridine nucleobase modification can mitigate the strong innate immune inflammatory response induced by in vitro synthesized mRNA, while boosting protein production. This removed a critical barrier to the clinical application of mRNA.

2014: Birth of GalNAc Liver-Targeted Delivery Technology — A Breakthrough for Oligonucleotide Industrialization

The GalNAc–ASGPR targeting strategy has been successfully developed and clinically validated by companies such as Alnylam and Ionis, enabling highly efficient hepatocyte delivery of oligonucleotides, subcutaneous dosing, and sustained gene silencing effects.

2014: Birth of GalNAc Liver-Targeted Delivery Technology — A Breakthrough for Oligonucleotide Industrialization

The GalNAc–ASGPR targeting strategy has been successfully developed and clinically validated by companies such as Alnylam and Ionis, enabling highly efficient hepatocyte delivery of oligonucleotides, subcutaneous dosing, and sustained gene silencing effects.

2018: Global First siRNA Drug Onpattro Approved — Nucleic Acid Drugs Officially Enter Commercialization

The FDA approved Alnylam’s Onpattro, the world’s first RNAi therapeutic, for the treatment of transthyretin amyloidosis.

2018: Global First siRNA Drug Onpattro Approved — Nucleic Acid Drugs Officially Enter Commercialization

The FDA approved Alnylam’s Onpattro, the world’s first RNAi therapeutic, for the treatment of transthyretin amyloidosis.

2020: Global Emergency Approval of mRNA COVID-19 Vaccines — Nucleic Acid Technology Achieved Mass Popularization

Amid the global COVID-19 pandemic, Pfizer-BioNTech and Moderna mRNA vaccines obtained emergency use authorization worldwide.

2020: Global Emergency Approval of mRNA COVID-19 Vaccines — Nucleic Acid Technology Achieved Mass Popularization

Amid the global COVID-19 pandemic, Pfizer-BioNTech and Moderna mRNA vaccines obtained emergency use authorization worldwide.

2021 Inclisiran: A Landmark Success in RNAi Therapeutics for Chronic Disease

Inclisiran represents a landmark success in RNAi therapeutics, demonstrating that GalNAc-enabled siRNA delivery can achieve durable, infrequent dosing and clinically meaningful LDL-C reduction, marking a major step in the transition of oligonucleotide drugs into mainstream chronic disease therapy.

2021 Inclisiran: A Landmark Success in RNAi Therapeutics for Chronic Disease

Inclisiran represents a landmark success in RNAi therapeutics, demonstrating that GalNAc-enabled siRNA delivery can achieve durable, infrequent dosing and clinically meaningful LDL-C reduction, marking a major step in the transition of oligonucleotide drugs into mainstream chronic disease therapy.

Technologies breakthrough in glycoscience field

1990s: Chemical enzymatic glycan synthesis.
1990s: Chemical enzymatic glycan synthesis.
Upon decades of work by researchers such as Yukio Ito, Qihui Weng, Peter Seeberger, and Peng George Wang, chemo-enzymatic glycan synthesis has evolved from laboratory-scale studies to “glycan factories,” where automation and AI-assisted synthesis are poised to fundamentally reshape the economic model of glycan production and access.
2000s:Synthetic biology of glycans.
2000s:Synthetic biology of glycans.
The industrialization of human milk oligosaccharides (HMOs) demonstrates the strong commercial viability of precision fermentation for glycan production. Building on this, we are actively expanding our presence in the synthetic biology space and have scaled up manufacturing of key glycan-related building blocks, including L-fucose and ManNAc.
2010s:Antibody-drug conjugate (ADC) glycoconjugation technology.
2010s:Antibody-drug conjugate (ADC) glycoconjugation technology.
Glycans can serve as precise anchors for targeted drug delivery. We have established a glycan remodeling–based ADC conjugation platform, integrating glycosidases and glycosyltransferases with copper-free click chemistry for efficient and site-specific conjugation.
2022:Click Chemistry
2022:Click Chemistry
The awarding of the 2022 Nobel Prize in Chemistry to click chemistry and bioorthogonal chemistry marks a Nobel-level tool revolution in glycoscience, promoted all-round breakthroughs of glycobiology in aqueous-phase reaction, precise synthesis, in vivo labeling and drug development.

1990s: Chemical enzymatic glycan synthesis.

2000s:Synthetic biology of glycans.

2010s:Antibody-drug conjugate (ADC) glycoconjugation technology.

2022:Click Chemistry

Blog Center

Working Together, Chasing the Light | Tangzhi Pharmaceutical 2025 New Year Gala


As the year turns and a new chapter unfolds, we look back on 2024, a year of progress and achievement for Tangzhi. This year, we held grand annual meetings in Wuhan, Qingdao, and Panjin, celebrating our successes together. Wuhan, as the headquarters of Tangzhi Pharmaceutical, holds our initial aspirations and dreams. In 2024, we achieved remarkable results. The company was successfully selected for Wuhan's "Backbone High-tech Enterprise Gazelle Plan" and recognized as a "Potential Unicorn" enterprise in the East Lake High-tech Development Zone, a "2024 Deloitte China High-Tech High-Growth 50 Strong" company, and a "2024 Deloitte Guanggu High-Tech High-Growth Top 20" company. Over the past year, Tangzhi Pharmaceutical has continued to focus on technological innovation and product development, resulting in steady revenue growth. At the Wuhan annual meeting, in his opening address, Chairman Wang Peng reviewed the outstanding achievements we made in technological innovation and market expansion, thanked every employee for their hard work, and looked forward to the new year, where we will continue to cultivate the fields of sugar and nucleic acids, providing even better products and services to global customers.

2025-01-27

Moving Forward with Honors, the Future is Bright | Tangzhi Pharmaceutical Ranks Among "Deloitte China's 2024 Top 50 High-Growth Technology Companies"


Recently, the "2024 Deloitte China Technology Fast 50" (hereinafter referred to as "China 50") was announced. Tangzhi Pharmaceutical, with its outstanding performance and rapid growth in the fields of sugar and nucleic acids, was honored to be on the list, ranking 15th with a revenue growth rate exceeding 690%! This honor is not only an affirmation of Tangzhi Pharmaceutical's innovative strength in the fields of sugar and nucleic acids, but also a commendation for its high-speed growth in a difficult environment. The Deloitte China Technology Fast 50 program has always been regarded as a "benchmark for high-growth companies globally." The selection of Tangzhi Pharmaceutical marks its leading position and strong competitiveness in the industry.

2025-01-21

New DNA-encoded chemical library technology to aid drug discovery and development


(Science and Technology Daily) Although researchers have made significant progress in the development of molecular therapies in recent years, the number of newly discovered active substances remains insufficient. Now, the DNA-encoded chemical library (DEL) technology, jointly developed by Harvard University in the US and ETH Zurich in Switzerland, offers a new solution. The technology can automate the synthesis and testing of billions of compounds in a matter of weeks, and can also be used to produce larger drug molecules that will act on targets that are difficult to reach with traditional small molecules.

2024-09-25